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</script> </div> </div> <section class="news"> <div class="news_view"> <ul> <li> <h1>온코닉테라퓨틱스, 셀트리온과 난소암 병용요법 임상 2상 신청</h1> <div class="view_img"> <p>최초입력 2025.10.01 15:59:34</p> <button type="button" class="btn_view btn_plus2" onclick='controlContentFontSize(0)'><span class="ico_comm ico_plus">크게</span></button> <button type="button" class="btn_view btn_min2" onclick='controlContentFontSize(1)'><span class="ico_comm ico_min">작게</span></button> </div> <div class="share_box"> <img src="//bimg.mk.co.kr/mkbn/mob/ic_sc2.png" width="29" alt="페이스북" onclick="sendThis('facebook');" data-label="facebook" data-category="share" class="sns_section_li" sns_name="facebook"> <img src="//bimg.mk.co.kr/mkbn/mob/ic_sc3.png" width="29" alt="트위터" onclick="sendThis('twitter');" data-label="twitter" data-category="share" class="sns_section_li" sns_name="twitter"> <a href="javascript:void(0);" data-label="kakaotalk" data-category="share"><img class="sns_section_li" sns_name="kakaotalk" 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data-width="522" data-height="78"></i> <span class="is_blind">사진 확대</span> </button> </div> <figcaption> </figcaption> </figure></div><p refId="2">온코닉테라퓨틱스는 차세대 항암신약 후보 ‘네수파립’과 셀트리온의 바이오시밀러 항암제 ‘베그젤마’ 병용요법에 대한 임상 2상 시험계획(IND)을 1일 식품의약품안전처에 신청했다.</p><p refId="3">이번 임상은 기존 난소암 표준 유지요법인 PARP 저해제 단독 사용 이후 치료 대안이 제한적인 상황에서, 두 약제를 병용해 ‘재유지요법’이라는 새로운 치료 옵션을 모색한다는 점에서 의미가 크다. 온코닉은 이번 연구를 통해 병용 투여의 안전성, 내약성, 항종양 효과를 종합적으로 검증할 계획이다.</p><p refId="4">네수파립은 PARP와 Tankyrase를 동시에 억제하는 이중저해 기전을 가진 합성치사 항암신약 후보물질로, 췌장암·위암·자궁내막암·난소암 등 고형암을 대상으로 개발이 진행되고 있다. 최근에는 진행성·전이성 췌장암 1차 치료제 임상 2상 진입을 승인받아 기대를 모았다.</p><p refId="5">병용 대상인 셀트리온의 베그젤마는 글로벌 주요 규제기관의 허가를 받은 VEGF 억제 항체 바이오시밀러로, 유럽에서 베바시주맙 계열 처방 1위를 기록 중이다.</p><p refId="6">온코닉은 이번 임상을 통해 두 약물의 시너지를 극대화해 글로벌 난소암 시장의 새로운 치료 패러다임을 제시하겠다는 목표다.</p><p refId="7">회사 관계자는 “전략적 협업을 통해 네수파립이 혁신 항암신약으로서의 가치를 입증하고, 난치성 암 환자들에게 새로운 치료 혜택을 제공할 수 있도록 최선을 다하겠다”고 말했다.</p><div id="refTotal" value="7"></div> [ⓒ 매일경제 & mk.co.kr, 무단 전재, 재배포 및 AI학습 이용 금지]</div> </li> </ul> 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